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In mathematics, a conic section (or just conic) is a curve obtained as the intersection of a cone (more precisely, a right circular conical surface) with a plane. In analytic geometry, a conic may be defined as a plane algebraic curve of degree 2. There are a number of other geometric definitions possible. One of the most useful, in that it involves only the plane, is that a conic consists of those points whose distances to some point, called a focus, and some line, called a directrix, are in a fixed ratio, called the eccentricity.
The conic sections were named and studied at least since 200 BC, when Apollonius of Perga undertook a systematic study of their properties.
St. Benedetto School presented the following dossier on conic sections
A science fair experiment is generally a competition where contestants present their science project results in the form of a report, display board, and models that they have created. Science fairs allow students in grade schools and high schools to compete in science and/or technology activities.
At the meeting in San Benedetto, our students participated in a science fair. Each school presented a scientific project and these are the results …
- I’m a sea Turtle Do you know my diet?
In this category we show the items related to the world of mathematics and science. We will design a magazin in each project meeting. The articles are written by students and teachers from each of the schools participating in the project.
Magazine nº 3 – San Benedetto del Tronto
Prof. Dr. Oktay Sinanoğlu
He is the youngest person in the past century to attain a status of professor
Oktay Sinanoğlu is a Turkish scientist of theoretical chemistry and molecular biology. He was the youngest person in the past century to attain a status of professor when he earned the status at the age of 28. Also, he has been nominated to Nobel award in chemistry twice. He is also one of the most successful people about protection of Turkish Language.
Sinanoğlu was born on February 25,1935 in Bari, Italy where his father served as a consul general. In 1939 by the commence of World War II, the family returned to Turkey. In 1953, he attended the high school “TED Yenişehir Lisesi” in Ankara, and after graduating won a scholarship for education of chemistry in the USA. In1956, he graduated from Berkeley in chemical engineering with the highest rank. In only eight months, he graduated from MIT in 1957 with the highest degree. In two years, he finished his doctorate at the University of California at Berkeley. In 1960, Sinanoğlu started working as associate professor at Yale University. He theorized the “Many-Electron Theory of Atoms and Molecules” in 1962 by solving a mathematical theorem that had been unsolved for 50 years. The same year, he earned the “Alfred P. Sloan” prize. As appointed professor in 1963 at the age of only 28, he became the youngest person in the past century at Yale to attain the status as a full professor. He got his second life-long chair in Yale in Molecular Biology.
Sinanoğlu was the first to earn the Alexander von Humboldt’s Science Prize in 1973. In 1975, he won the award of Japan’s International Outstanding Scientist. In the 1980s, he theorized a new method from 180 theories concerning mathematics and physics, considered revolutionary, which enables chemists to predict the ways in which chemicals combine in the laboratory and to solve other complex problems in chemistry using simple pictures and periodic tables. Also, he took his place in the Academy of Arts & Sciences. In 1993, he moved to Turkey to teach at the Yıldız Teknik Universitesi, and officially retired at the age of 67. Yet his scientific researches has not ceased.
He received several international and local awards concerning his scientific and social contributions and efforts. He has been to many places includingAsia and Latin America. He tried to establish strong communications between Japan, India and Turkey. Because of his efforts, he was given the title “Special Emissary” of Japan-Turkey. He worked for better education, purified language in Turkey most of his life and strived to form a conscious generation.
Fuat Sezgin: A life devoted to understanding Islam’s golden age of science
Fuat Sezgin founded two museums in İstanbul and Frankfurt that bring together hundreds of replicas of scientific instruments, tools and maps, mostly belonging to the golden age of Islamic science.(PHOTO Sunday’s Zaman)
25 December 2011 /MAHMUT ÇEBI
Fuat Sezgin, a Turkish researcher and historian who has devoted his life to uncovering the roots of Islamic civilization and how big a role the Islamic world played in the emergence of today’s modern civilization, has always found it astonishing that so little is known about the scientific achievements of the Islamic world.
Known as the “conqueror of a missing treasure,” Sezgin was inspired by Helmut Ritter, a renowned 20th century German scholar of oriental studies and someone who used to teach courses on Islamic sciences and orientalism at İstanbul University.
Ritter inspired Sezgin to begin his search for the Islamic scholars’ contributions to modern science. Sezgin defines the moment he met with Ritter as “the time when I was born again.” He said Ritter told him to read at least 17 hours a day if he wanted to become a real scholar.
During one of Ritter’s courses, Sezgin asked him whether or not there was an important Islamic mathematician and was surprised by his answer: “There are as many mathematicians in the Islamic world as there are great figures in Greece and Europe,” Ritter said. The reason why Sezgin was astonished by Ritter’s answer was due to the fact that one of his teachers at primary school told him that Muslims scholars used to believe that the earth was located on the horn of an ox.
Sezgin said it was following the statements by Professor Ritter that he started to take notice of the fact that the Islamic world had made significant contributions to the history of general sciences and decided to search for what those contributions were.
“From that day on, I decided to learn about the contributions of the Islamic world to science and to make a contribution to science myself if possible. Despite my young age, I assumed the responsibility of writing the ‘History of Islamic Sciences.’ I worked day and night on that book,” Sezgin said.
Sezgin decided to first address the question of “when Islamic narration began and from which period on it is possible to talk about written Islamic documents.” After graduating from the faculty of literature of İstanbul University in 1947, Sezgin received his Ph.D. in 1954 for his work on Arab language and literature. In 1954 he became an associate professor with his work titled “Buhari’nin Kaynakları” (Sources of Bukhari).
Bukhari refers to Muhammad al-Bukhari, a Sunni Islamic scholar from Persia who authored the Hadith collection titled “Sahih al-Bukhari.” In his book, Sezgin claims that Bukhari relied on written sources for the Hadith, and not oral sources as is widely believed.
During his years as a student, Sezgin also read Carl Brockelmann’s five-volume “History of Arab Literature,” which was written based on manuscripts in Europe and İstanbul. Sezgin found out that this book, which details chronological information about manuscripts and gives tips to researchers on how to access these manuscripts, did not include information about many Muslim authors. Brockelmann, who used to come to İstanbul occasionally for a one-month’s stay, did not have sufficient time before his death to expand his body of work. Upon noticing that most of the written Islamic sources were not included in Brockelmann’s work, Sezgin decided to complete his work, which would mean examining hundred of thousands of works, something that would last for decades.
Sezgin was not the only person who wanted to complete Brockelmann’s work, as a group of European scholars made a similar attempt in the 1950s under the leadership of the Brill Publishing House, which published German translations of Arabic works. This group of scholars was able to complete Brockelmann’s work thanks to financial support from UNESCO.
Sezgin travelled to Germany for several times during 1957 and 1958, where he worked at University of Bonn. The scholar improved his German to the extent that he began offering his courses in German. Although he was asked to stay at the university, Sezgin declined the offer and returned to Turkey, where he established the Islamic Sciences Research Institute with Zeki Velidi Togan, a Turkish historian.
The May 27, 1960 military coup was a turning point in Sezgin’s life. He said that even though two of his brothers were jailed in the aftermath of the coup, he tried to continue his studies but was shocked by the news of the removal of 147 professors from the university.
“As I was going to the institute one morning, I was shocked to hear a boy selling newspapers telling me about the removal of 147 professors from the university. I was either the 40th or 50th among the professors who were removed. I did not want to leave my country, but when I was removed from the university, I saw that I had no other choice. I went to the Süleymaniye Library and wrote letters to my friends, two Americans and the former rector of Frankfurt University, asking them whether they could find me a place to continue my studies as I had been expelled from the university. I received positive responses from all three of them within a month. I chose to work in Frankfurt. On the evening of my departure from Turkey, I went to the Karaköy side of the Galata Bridge. I watched Üsküdar for about 15 or 20 minutes. It was a beautiful night, but I had to wipe my tears. I was not angry but sad,” he said.
Sezgin began offering courses at the University of Frankfurt as a visiting professor in 1961, where he was very well liked by his students due to his disciplined work ethic and character.
In 1967, the first volume of Sezgin’s “Islam’s Golden Age of Science,” which was an expansion of Brockelmann’s work, was published, receiving widespread acclaim in academic circles.
Visiting more than 60 countries, Sezgin examined works in the fields of physics, chemistry, biology, animal breeding, veterinary medicine, agriculture, medicine, astronomy and geography for the “History of Islamic Sciences,” and brought these works, which were kept on the dusty shelves of the libraries of many countries, to light so that they could be accessed by researchers.
The number of volumes of his study reached 15 over the years.
Sezgin founded a unique museum in 1983, bringing together more than 800 replicas of historical scientific instruments, tools and maps, mostly belonging to the golden age of Islamic science. A similar museum was opened in 2008 in İstanbul.
The 87-year-old Sezgin still works 14 hours a day. He plans to publish the 16th and 17th volumes of his study of Islamic sciences next year, which will deal with “literary sciences in the Arabic language.”
Due to his contribution to science in Europe, Sezgin has been awarded the Great Medal for Distinguished Service of the Federal Republic of Germany Although he has been living abroad away for roughly a half century, he is still a Turkish citizen and declined offers from Germany to be granted German citizenship
Aydogan Ozcan has the Ph.D., the expertise, and the engineering acumen to perfect the world’s most complex medical diagnostic technology. Instead, he’s solving global health issues—with a cell phone.
His UCLA research team has invented a way to turn common cell phones, already in the hands of four billion people worldwide, into imaging tools that will bring accurate medical diagnoses to the most remote, resource-poor corners of the planet.
“Very few of the great technologies we play with in advanced countries can actually be applied in developing parts of the world,” he points out. “You can’t even assume there will be consistent electricity in rural clinics or villages. Because the infrastructure gap is so huge, we aren’t delivering our best thinking to the people who need it most. I find that very disturbing.”
To demonstrate the gap, Ozcan points to sophisticated $100,000 blood count analyzers found in advanced labs. He feels they are already so state of the art that any improvements will be merely incremental. But in developing nations, even basic technology can be transformative. “Since there’s virtually nothing there to start with, it’s much easier to make a huge impact, quickly.”
In many rural villages, patients remain untreated until mobile units reach them. Even then, tools are woefully inadequate. “You can’t afford to take hundreds of blood samples, transport them to a hospital, then return with results,” he explains. “Many diseases remain entirely missed; people are dying from simple infections that could be easily treated if only they were diagnosed.”
Conventional microscopes, the mainstay of diagnosis for centuries, are impractical on a global level. “They are too heavy and powerful to be cost-effectively miniaturized. They also can’t quickly capture and screen the large number of cells needed for statistically viable diagnoses,” he says.
What’s more, because technicians in remote areas may be poorly trained, they often interpret images inaccurately. “In some parts of Africa, 70 percent of malaria diagnoses are incorrect false-positives.”
These constraints convinced Ozcan that rather than inventing another new ultrahigh-performance tool, we need to think like engineers: “Who’s going to use it and how much can I spend?” This mindset led him directly to cell phones.
“Here’s this extremely inexpensive, yet advanced, technology that’s in use almost everywhere. It presents an obvious opportunity that can be leveraged to benefit health environments where cost drives everything,” he says. “So that’s what we’re doing—creating digital technologies that replace microscopes and enable cell phones to make diagnostic decisions, even in a distant desert village.”
Ozcan’s invention solves the dilemma of poorly trained technicians by arming the phones with sophisticated algorithms that do the interpreting. To tackle the most expensive part of microscopes—lenses—his team simply eliminated them.
“With our lens-free imaging platform, instead of detecting the cell, we detect its shadow,” he explains. “When you shine light on a cell, it casts a shadow from which we can reconstruct the cell image, perform advanced processing, and detect signatures of disease. We’re able to do this because unlike flat, dark, human shadows, the shadows of cells are semitransparent, very textured, and contain specific fingerprints.”
Ozcan’s modified phone uses a special light source and the phone’s camera to capture an image of a blood sample, essentially turning the phone into a lens-free microscope. “It’s lightweight, instantly shows us huge numbers of cells, and fits into the palm of your hand.”
Field tests slated to begin this year will distribute hundreds of the devices to mobile health units in rural Africa with a focus on diagnosing malaria. A central, inexpensive PC station will be installed in a hospital. Mobile health workers will collect blood, load images of the samples into the modified phones, and transmit them to the PC station via the Internet. Within minutes, the data will be processed and a summary diagnosis sent back into the field. Records will also be stored, creating an unprecedented database of global disease statistics.
“Treating malaria is actually very simple,” Ozcan notes, “What’s been lacking is the diagnosis.” Using the devices to analyze blood and other bodily fluids will also be crucial in detecting tuberculosis, HIV/AIDS, and other conditions. Additionally, wireless telemedicine platforms can be a much needed breakthrough in monitoring patients. “Today, HIV doesn’t have to be deadly. If patients are monitored regularly it can be controlled. The ability to easily, frequently check patients would allow us to treat HIV like diabetes, saving so many lives.”
The future, Ozcan believes, lies not only in new technologies, but in innovative applications of existing technologies. Blending an engineer’s discipline and a social entrepreneur’s heart, he predicts, “That’s what will transform global health care in powerful, practical ways we’ve never before imagined.”
Enrico Fermi was an Italian theoretical and experimental physicist, best known for his work on the development of Chicago Pile-1, the first nuclear reactor, and for his contributions to the development of quantum theory, nuclear and particle physics, and statistical mechanics. Along with Robert Oppenheimer, he is referred to as “the father of the atomic bomb”. He was also regarded as one of the very few physicists who excelled both theoretically and experimentally. He was born in Rome on 29th September 1901 He attended a local grammar school, and his early aptitude for mathematics and physics was recognized. In July 1918 he graduated from the high school and, at Amidei’s urging, applied to the Scuola Normale Superiore in Pisa.
Having lost one son, his parents were reluctant to let him go away for four years instead of living at home while attending the University of Rome, but in the end they acquiesced. The school provided free lodging for students but candidates had to take a difficult entrance exam, which included an essay. The given theme was “Specific characteristics of Sounds”. The examiner, professor Giuseppe Pittarelli from the University of Rome, interviewed Fermi and concluded that his entry would have been commendable even for a doctoral degree. Fermi achieved first place in the classification of the entrance exam. Between 1919 and 1923 Fermi initially chose mathematics as his major, but soon switched to physics. He remained largely self-taught, studying general relativity, quantum mechanics and atomic physics. He’s knowledge of quantum physics reached such a high level that Puccianti, director of the Institute of Physics at the Normal School, asked him to organize seminars on the topic.
In September 1920, Fermi was admitted to the Physics department. There were only three students. Puccianti let them use the laboratory for whatever they wanted. Fermi then decided that they should research X-ray crystallography, and the three worked to produce a Laue photograph, an X-ray photograph of a crystal. in 1923, Fermi pointed out, for the first time, that hidden inside the famous Einstein equation (E = mc2) was an enormous amount of nuclear potential energy to be exploited. “It does seem possible, at least in the near future”, he wrote, “to find a way to release these dreadful amounts of energy—which is all to the good because the first effect of an explosion of such a dreadful amount of energy would be to smash into smithereens the physicist who had the misfortune to find a way to do it.” thanks to a scholarship, he went to Göttingen for six months at the school of Max Born but the period in Göttingen did not prove very fruitful. Fermi’s first major contribution was to statistical mechanics.
After Wolfgang Pauli announced his exclusion principle in 1925, Fermi followed with a paper in which he applied the principle to an ideal gas, employing a statistical formulation now known as Fermi–Dirac statistics. Fermi–Dirac statistics describes distribution of particles in a system comprising many identical particles that obey the Pauli exclusion principle. It is named after Enrico Fermi and Paul Dirac, who each discovered it independently, although Enrico Fermi defined the statistics earlier than Paul Dirac. Fermi–Dirac (F–D) statistics applies to identical particles with half-odd-integer spin in a system in thermal equilibrium. Additionally, the particles in this system are assumed to have negligible mutual interaction. This allows the many-particle system to be described in terms of single-particle energy states. The result is the F–D distribution of particles over these states and includes the condition that no two particles can occupy the same state, which has a considerable effect on the properties of the system. Since F–D statistics applies to particles with half-integer spin, these particles have come to be called fermions. It is most commonly applied to electrons, which are fermions with spin 1/2. Fermi–Dirac statistics is a part of the more general field of statistical mechanics and uses the principles of quantum mechanics.
For a system of identical fermions, the average number of fermions in a single-particle state , is given by the Fermi–Dirac (F–D) distribution,
where k is Boltzmann’s constant, T is the absolute temperature, is the energy of the single-particle state , and is the chemical potential. At T = 0 K, the chemical potential is equal to the Fermi energy. For the case of electrons in a semiconductor, is also called the Fermi level. The F–D distribution is only valid if the number of fermions in the system is large enough so that adding one more fermion to the system has negligible effect on ,or if the system is able to exchange particles with a reservoir. Since the F–D distribution was derived using the Pauli exclusion principle, which allows at most one electron to occupy each possible state, a result is that .
• Fermi–Dirac distribution •
In 1926, at the age of 24, he applied for a professorship at the University of Rome. Two years later he married Laura Capon, a science student at the University. During their time in Rome, Fermi and his group made important contributions to many practical and theoretical aspects of physics. In 1928, he published his “Introduction to Atomic Physics”,which provided Italian university students with an up-to-date and accessible text. Fermi also conducted public lectures and wrote popular articles for scientists and teachers in order to spread knowledge of the new physics as widely as possible. Part of his teaching method was to gather his colleagues and graduate students together at the end of the day and go over a problem, often from his own research. A sign of success was that foreign students now began to come to Italy.
At this time, physicists were puzzled by beta decay, in which an electron was emitted from the atomic nucleus. To satisfy the law of conservation of energy, Pauli postulated the existence of an invisible particle with no charge that was also emitted at the same time. Fermi took up this idea, which he developed in a tentative paper in 1933, and then a longer paper the next year that incorporated the postulated particle, which Fermi called a “neutrino“. His theory, later referred to as Fermi’s interaction, and still later as the theory of the weak interaction, described one of the four forces of nature. The neutrino would not be detected until after his death, and his interaction theory showed why it was so difficult to detect. When he submitted his 1934 paper to the British journal Nature, that journal’s editor turned it down because it contained speculations which were “too remote from physical reality to be of interest to readers”. Thus Fermi saw the theory published in Italian and German before it was published in English.
After his difficult time with beta decay, Fermi decided to switch to experimental physics, using the neutron.The result would be a burst of more than twenty papers by Fermi and his collaborators. In 1934 husband and wife curie bombarded elements with alpha particles and induced radioactivity in them. Fermi suggested that they perform the same experiment with neutrons, which would theoretically work better because neutrons had no electric charge, and so would not be deflected. They constructed a neutron source from radium and beryllium and started bombarding elements, starting with hydrogen, and working their way up the periodic table. Nothing registered on their Geiger counter until they reached fluorine and aluminium, which emitted an alpha particle and decayed into calcium.
They also noticed some unexplained effects. The experiment seemed to work better on a wooden table than a marble table top. Fermi decided to try placing some lead in the path of the neutron source, but then, remembering that Joliot-Curie and Chadwick had noted that paraffin wax was more effective than lead at slowing neutrons, he decided to try it instead. The paraffin induced a hundred times as much radioactivity in silver. He guessed that this was due to the hydrogen atoms in the paraffin, and confirmed this by repeating the effect with water. He concluded that slow neutrons were more easily captured than fast ones, and developed a diffusion equation to describe this, which became known as the Fermi age equation.
Fermi’s group systematically bombarded elements with slow neutrons. When they reached thorium and uranium, the natural radioactivity of these elements made it hard to determine what was happening, but they concluded that they had created new elements, which they called hesperium and ausonium. At that time, fission was thought to be improbable if not impossible, mostly on theoretical grounds. While people expected elements with higher atomic numbers to form from neutron bombardment of lighter elements, nobody expected neutrons to have enough energy to actually split a heavier atom into two light element fragments, and it was thought still more unlikely that slow neutrons could accomplish such a task. However, he had not taken into account the “pairing energy” that would appear when a nuclide with an odd number of neutrons absorbed an extra neutron.
In 1938, Fermi received the Nobel Prize in Physics at the age of 37 for his “demonstrations of the existence of new radioactive elements produced by neutron irradiation, and for his related discovery of nuclear reactions brought about by slow neutrons”. After Fermi received the Nobel Prize in Stockholm, he, his wife Laura, and their children did not return home to Italy, but rather continued to New York City, where they applied for permanent residency. The decision to move to America and become American citizens was primarily a result of the racial laws promulgated by Mussolini in order to bring Italian Fascism ideologically closer to German National Socialism. The new laws threatened Laura, who was Jewish, and put many of Fermi’s research assistants out of work.
During the last years of his life Fermi occupied himself with the problem of the mysterious origin of cosmic rays, thereby developing a theory, according to which a universal magnetic field – acting as a giant accelerator – would account for the fantastic energies present in the cosmic ray particles.
He died in Chicago on 28th November, 1954
Impressions from Târgu Jiu
What do Turkish students think about Romania trip and The Romenian Evening? First of all it was an academic trip. We came accross and science in our life, we saw that how we use maths and science in our jobs. Another thing is that it was an interesting trip, such as I’ve never been in a bat cave before. And it was a little bit stressful trip because of the science fair as we have a presentation.
Than science fair ! First we were a little bit nervous about the science fair and everything was prepared when we came . Then we put the cartoons together and saw the other projects , they were also different and that’s why we were so excited. After our presantation we listened other projects. And we think that about science fair, it was enjoyable, informative and we saw that the young brains can create good ideas !
Another point is we think the teachers and hosts ( also hostesses )
were really sympathic then we thought, their English were not bad so we could communicate, we made funny and cultural conversations. In this way we find a chance to learn some different things about other countries culture, especially Polishs! And we learnt some simple words and sentences from other languages.
The accommoation was better than we expected. And the organisation was perfect and the meals were quite delicious. Let’s talk about the Romenian Evening. This evening was really funny and it was tiring, just because of dances, especially Turkish dances
were fast, so they were tiring! On the other hand , the band, meal, music, restaurant were good. We really enjoyed it! And I should say that Romenian dances were a little bit difficult. The funniest thing of this evening was that the other students try to do Turkish dances. By the way it was a good chance for introducing our culture. At the end of this evening, was the best night of the trip.
I hope, you like Turkish and Turkish culture.
By: Turkish team
A day in the cave
We are Adrian, Jesus and Angela. We study in the first degree at the secondary school “IES Miguel Romero Esteo” from Málaga. We have participated in a meeting in Romania and we would like to write about one of the activities that we liked.
That day, we went by bus to a town that was far away, we took too long to arrive because the roads were very bad. In this village we saw a man working with ceramics and we sat down and we made the same. From there we were taken to a cave where there was a very beautiful landscape.
The cave was a “cave alive” as it is still being formed, the guide talked about the stalactites (extensions to the ceiling), stalagmites (floor extensions) and pillars are stalactites and stalagmites together, also said that form when rain water leaking from the roof and that is a very slow process, so that in about 100 or 150 million years only grow 2.5 inches of rock.
The climate is European continental that means very cold in winter and very hot in summer which contrasts sharply with the Mediterranean climate where, there is not abrupt temperature changes.
It was a very enjoyable day. We hung out with students from other schools and enjoyed. We hope to return someday
24 February, the day of the departure.
Four guys and two teachers of Liceo Classico “G.Leopardi” were leaving from San Benedetto del Tronto to Romania, to take part to the Comenius project.
We were all excited and full of expectations, the account of the guys who had been in Poland, had made us really curious but a bit scared.
We didn’t know what was expecting us and most of all we ignored how that experience would been. Despite that, we got soon surprised!
Everything was perfectly organized, we had an intense programme to follow: we either stayed at school and followed lessons or we visited places of historical, cultural and scientific interest.
They were always occasions to meet the other European partners, to know them, to discover new interesting things about places we had never seen before.
Moreover we spoke English most of the time and it was a good fun even when we made mistakes, because we were communicating anyway. Our impressions now that we are back to daily routine at home and at school are that this kind of experiences is so important to learn more about the world we live in and people different from us.
What we will never forget is the atmosphere with our international friends: lively, direct and spontaneous at first sight!
This is why we are looking forward to meeting and hosting them soon here in
One of tourist attractions during our stay in Romania was a trip to the village of Horezu which took place on Wednesday 27th February.
Horezu is a village famous for pottery and ceramics that is made there. We could observe the traditional way of making pottery goods by a local craftsman who was using a kick wheel to shape plates and bowls. We have learned that men and women have different tasks in creating pottery products . Men use a kick wheel to form the shapes of plates, bowls or jugs whereas women are responsible for decorating and painting them.
There are a lot of symbols hand painted on Horezu pottery , but the most popular image is a rooster drawn in black and brown colour. Other images include the tree of life, a snake, stars and a simple spiral.
The traditional material of which pottery is made in Horezu is local clay that comes from the area of nearby mountains and neighbouring villages. The most common colours for the pottery painting are earth tones, such as orange and brown as well as ornaments in green and blue.
The village of Horezu is very picturesque because the front of almost each house is richly decorated with beautiful hand- made plates. Both teachers and students bought there plates and bowls to have some souvenirs from that magical place . Also local people were friendly to our group, especially one elderly woman who (anyway, we are foreigners from different parts of the world!) invited us to look inside her house and to see more pottery plates as each house in Horezu has its own collection of these wonderful earthenware.
The Multilingual dictionary is a work done by students in 7 countries of the European Union within the framework of the Comenius project “Math and Science”.
Our goal is that our students know the most common scientific terms and that they can translate into several languages.
The dictionary consists of 4 documents with the words used in the fields of mathematics, physics, biology and chemistry.
(February 22, 1914 – February 19, 2012)
Renato Dulbecco was an Italian virologist who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells. He studied at the University of Turin under Giuseppe Levi, along with fellow students Salvador Luria and Rita Levi-Montalcini, who also moved to the U.S. with him and won Nobel prizes. He was drafted into the Italian army in World War II, but later joined the resistance.
Dulbecco was born in Catanzaro (Southern Italy) to a Calabrese mother and a Ligurian father. He graduated from high school at 16, then moved to theUniversity of Turin. Despite a strong interest for mathematics and physics, he decided to study medicine. At only 22, he graduated in morbid anatomyand pathology under the supervision of professor Giuseppe Levi. During these years he met Salvador Luria and Rita Levi-Montalcini, whose friendship and encouragement would later bring him to the United States. In 1936 he was called up for military service as a medical officer, and later (1938) discharged. In 1940 Italy entered World War II and Dulbecco was recalled and sent to the front in France and Russia, where he was wounded. After hospitalization and the collapse of Fascism, he joined the resistance against the German occupation.
After the war he resumed his work at Levi’s laboratory, but soon he moved, together with Levi-Montalcini, to the U.S., where, in Bloomington, Indiana, he worked with Salvador Luria on bacteriophages. In the summer of 1949 he moved to Caltech, joining Max Delbrück’s group. There he started his studies about animal oncoviruses, especially of polyoma family. In the late 1950s, he took Howard Temin as a student, with whom, and together with David Baltimore, he would later share the 1975 Nobel Prize in Physiology or Medicine for “their discoveries concerning the interaction betweentumour viruses and the genetic material of the cell.” Temin and Baltimore arrived at the discovery of reverse transcriptase simultaneously and independently from each other; although Dulbecco did not take direct part in either of their experiments, he had taught the two methods they used to make the discovery.
(Dulbecco working in laboratory)
Throughout this time he also worked with Marguerite Vogt. In 1962, he moved to the Salk Institute and then in 1972 to The Imperial Cancer Research Fund (now named the Cancer Research UK London Research Institute). In 1986 he was among the scientists who launched the Human Genome Project. From 1993 to 1997 he moved back to Italy, where he was president of the Institute of Biomedical Technologies at C.N.R. (National Council of Research) in Milan. He also retained his position on the faculty of Salk Institute for Biological Studies. Dulbecco was actively involved in research into identification and characterization of mammary gland cancer stem cells until December 2011. His research using a stem cell model system suggested that a single malignant cell with stem cell properties may be sufficient to induce cancer in mice and can generate distinct populations of tumor-initiating cells also with cancer stem cell properties. Dulbecco’s examinations into the origin of mammary gland cancer stem cells in solid tumors was a continuation of his early investigations of cancer being a disease of acquired mutations. His interest in cancer stem cells was strongly influenced by evidence that in addition to genomic mutations, epigenetic modification of a cell may contribute to the development or progression of cancer.
Dulbecco and his group demonstrated that the infection of normal cells with certain types of viruses (oncoviruses) led to the incorporation of virus-derived genes into the host-cell genome, and that this event lead to the transformation (the acquisition of a tumor phenotype) of those cells. As demonstrated by Temin and Baltimore, who shared the Nobel Prize with Dulbecco, the transfer of viral genes to the cell is mediated by an enzyme called reverse transcriptase (or, more precisely, RNA-dependent DNA polymerase), which replicates the viral genome (in this case made of RNA) into DNA, which is later incorporated in the host genome.
(Dulbecco, Nobel Prize award ceremony 1975)
Oncoviruses are the cause of some forms of human cancers. Dulbecco’s study gave a basis for a precise understanding of the molecular mechanisms by which they propagate, thus allowing humans to better fight them. Furthermore, the mechanisms of carcinogenesis mediated by oncoviruses closely resemble the process by which normal cells degenerate into cancer cells. Dulbecco’s discoveries allowed humans to better understand and fight cancer. In addition, it is well-known that in the 1980s and 1990s, an understanding of reverse transcriptase and of the origins, nature, and properties of human immunodeficiency virus (HIV, of which there are two well-understood serotypes, HIV-1, and the less-common and less virulent HIV-2), the virus which, if unchecked, ultimately causes acquired immunodeficiency syndrome (AIDS), led to the development of the first group of drugs that could be considered successful against the virus, the reverse transcriptase inhibitors, of which zidovudine is a well-known example. These drugs are still used today as one part of the highly-active antiretroviral therapy drug cocktail that is in contemporary use.
In 1973 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Theodore Puck and Harry Eagle. Dulbecco was the recipient of the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1974.
Eagle’s minimal essential medium is a cell culture medium developed by Harry Eagle that can be used to maintain cells in tissue culture.
• amino acids
• salts (calcium chloride, potassium chloride, magnesium sulfate, sodium chloride, and monosodium phosphate)
• vitamins (folic acid, nicotinamide, riboflavin, B12)
A variation of this EMEM, called Dulbecco’s modiﬁed Eagle’s medium (DMEM), (Dulbecco/Vogt modified Eagle’s minimal essential medium), contains approximately four times as much of the vitamins and amino acids present in the original formula and two to four times as much glucose. Additionally, it contains iron and phenol red. DMEM is suitable for most types of cells, including human, monkey, hamster, rat, mouse, chicken and fish cells.